Carvacrol was encapsulated by β-cyclodextrin, and spray dried by the nano s pray dryer B-90. The nanoparticle was applied as a sachet to preserve limes. The data set contains the physical and chemical properties of the nanoparticles, including encapsulation efficiency, Fourier transform infrared information , release profile, particle diameter, antimicrobial activity, and antioxidant activity. The nanoparticles were applied to preserve postharvest limes; fruit firmness, soluble solid content, titratable acid, weight loss, peel color change, and microbial count were shown in the data set. The data set provides evidence of nanoparticles preserving and extending the shelf life of postharvest fruit.