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Transcriptomics and Metabolomics Reveal Liver Metabolic Changes and Phytochemical Deposition Occurring after Tomato Consumption in Mice

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posted on 2024-06-11, 07:00 authored by Pediatrics, USDA-ARS Children's Nutrition Research Center

Tomato consumption is associated with many health benefits including lowered risk for developing certain cancers. However, the effects of tomato consumption on gene expression and the chemical profile of mammalian liver are not well defined. Overall design: C57BL/6 mice (n=11-12/group) were fed a macronutrient matched diet containing either 10% red tomato, 10% tangerine tomato, or no tomato powder for 6 weeks after weaning. RNA-Seq followed by gene set enrichment analyses indicated that tomato type and consumption, in general, altered expression of phase I and II xenobiotic metabolizing genes.

History

Data contact name

BioProject Curation Staff

Data contact email

bioprojecthelp@ncbi.nlm.nih.gov

Publisher

National Center for Biotechnology Information

Temporal Extent Start Date

2022-12-17

Theme

Non-geospatial

ISO Topic Category

biota

National Agricultural Library Thesaurus terms

transcriptome; gene expression

Pending citation

Public Access Level

Public

Accession Number

PRJNA913439

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It is recommended to cite the accession numbers that are assigned to data submissions, e.g. the GenBank, WGS or SRA accession numbers. If individual BioProjects need to be referenced, state that "The data have been deposited with links to BioProject accession number PRJNA913439 in the NCBI BioProject database (https://www.ncbi.nlm.nih.gov/bioproject/)."

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Keywords

Mus musculus eEukaryotes

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