Ag Data Commons
Browse

RNA-sequencing of trigeminal ganglia from calves latently infected with bovine herpesvirus 1

dataset
posted on 2025-01-22, 05:16 authored by Oklahoma State University
Bovine herpesvirus 1 (BoHV-1) is the causative agent of infectious bovine rhinotracheitis, a highly contagious respiratory disease characterized by significant inflammation in the upper respiratory tract of cattle. Infection with BoHV-1 predisposes cattle to secondary bacterial pneumonia and can also lead to infertility and abortions. Following the initial infection, BoHV-1 establishes a lifelong latency within sensory neurons of the trigeminal ganglia (TG). Various factors including stress, immunosuppression, or hormone fluctuations can trigger reactivation and further transmission of the virus. To explore the molecular mechanisms occurring during latency, we conducted RNA sequencing on TG samples from calves uninfected or latently infected with BoHV-1. Understanding these molecular pathways is crucial for developing effective strategies to prevent BoHV-1 reactivation and control its transmission among cattle.

Funding

USDA: 2023-07864

USDA: 2020-06435

History

Data contact name

BioProject Curation Staff

Publisher

National Center for Biotechnology Information

Temporal Extent Start Date

2024-10-25

Theme

  • Non-geospatial

ISO Topic Category

  • biota

National Agricultural Library Thesaurus terms

sequence analysis

Pending citation

  • No

Public Access Level

  • Public

Accession Number

PRJNA1177818

Preferred dataset citation

It is recommended to cite the accession numbers that are assigned to data submissions, e.g. the GenBank, WGS or SRA accession numbers. If individual BioProjects need to be referenced, state that "The data have been deposited with links to BioProject accession number PRJNA1177818 in the NCBI BioProject database (https://www.ncbi.nlm.nih.gov/bioproject/)."

Usage metrics

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC