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Metagenomic sequencing of diabetes progression in the UC Davis Type 2 Diabetes Mellitus Rat Model

dataset
posted on 2024-06-11, 05:50 authored by Arkansas Children's Nutrition Center
The aim of this study was to characterize how changes in host metabolic health alters the cecal microbiome in a diet independent rat model of diabetes. While there are several reports in humans and rodents describing differing gut bacterial communities in obese/diabetic groups compared to normal weight and/or healthy groups, it is not known whether this is due to differences in dietary intake or mediated by obesity and or differences in host physiology. The UC Davis Type 2 Diabetes Mellitus (UCDT2DM) Rat model spontaneously develops adult-onset diabetes with functional leptin signaling, providing a rodent model that most closely resembles the pathogenesis of type 2 diabetes in humans. We assessed differences in bacterial taxonomic and functional gene clusters in age matched sets of male UCDT2DM rats at differing stages of diabetes progression: Prior to the onset of diabetes (PD n=15), 2 weeks post onset of diabetes (RD, n=10), 3 months post onset of diabetes (D3M, n=11), and 6 months post onset of diabetes (D6M, n=8). Lean Sprague Dawley rats were used as a model of healthy non-diabetic controls (LSD, n=12).

Funding

Agricultural Research Service, 5306-51530-019-00

National Institute of General Medical Sciences, P20 GM121293

National Heart, Lung, and Blood Institute, R01 HL091333

National Heart, Lung, and Blood Institute, R01 HL107256

National Heart, Lung, and Blood Institute, R01 HL121324

National Institute of Diabetes and Digestive and Kidney Diseases, R01DK078328

National Institute of Diabetes and Digestive and Kidney Diseases, R01DK095060

National Institute of Diabetes and Digestive and Kidney Diseases, RC1 DK087307

National Institute of Diabetes and Digestive and Kidney Diseases, U24 DK092993

History

Data contact name

BioProject Curation Staff

Publisher

National Center for Biotechnology Information

Temporal Extent Start Date

2018-04-18

Theme

  • Non-geospatial

ISO Topic Category

  • biota

National Agricultural Library Thesaurus terms

sequence analysis

Pending citation

  • No

Public Access Level

  • Public

Accession Number

PRJNA450767

Preferred dataset citation

It is recommended to cite the accession numbers that are assigned to data submissions, e.g. the GenBank, WGS or SRA accession numbers. If individual BioProjects need to be referenced, state that "The data have been deposited with links to BioProject accession number PRJNA450767 in the NCBI BioProject database (https://www.ncbi.nlm.nih.gov/bioproject/)."

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