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Inter-individual Variation of Sulforaphane and Sulforaphane-Nitrile Excretion in Humans is Influenced by Gut Microbiome Composition

dataset
posted on 2024-01-27, 00:40 authored by Oregon State University
The glucosinolate glucoraphanin from broccoli can be converted to sulforaphane (SFN) or sulforaphane-nitrile (SFN-NIT) by endogenous plant enzymes or members of the gut microbiome. Human feeding studies typically observe high levels of inter-individual variation in absorption and excretion of SFN, however, the source of this variation is not fully known. Participants were fed broccoli or alfalfa sprouts and plasma, stool samples, and total urine was collected over 72 hours. SFN-metabolites were quantified in each tissue and participant gut microbiomes were profiled using 16S gene sequencing.

Funding

National Institute of Food and Agriculture, 2020-67001-31214

National Institute of Food and Agriculture, 2022-67011-36576

National Institute of Environmental Health Sciences, P30 ES030287

National Center for Research Resources, S10 RR027878

History

Data contact name

BioProject Curation Staff

Publisher

National Center for Biotechnology Information

Temporal Extent Start Date

2023-04-07

Theme

  • Non-geospatial

ISO Topic Category

  • biota

National Agricultural Library Thesaurus terms

sequence analysis

Pending citation

  • No

Public Access Level

  • Public

Accession Number

PRJNA953404

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