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Effects of Ceftiofur and Chlortetracycline on the Resistome of Feedlot Cattle

dataset
posted on 2024-01-27, 05:03 authored by Colorado State University
Treatment of food producing animals with antimicrobial drugs (AMD) is controversial because of concerns regarding promotion of antimicrobial resistance (AMR). To investigate this concern, resistance genes in metagenomic fecal samples during a clinical trial were analyzed to assess the impacts of treatment on beef feedlot cattle resistomes. Four groups of cattle were exposed, using a 2x2 factorial design, to different regimens of antimicrobial treatment. Injections of ceftiofur crystalline free acid (a third generation cephalosporin) were used to treat all cattle in treated pens vs. only a single animal, and chlortetracycline was included in the feed of all cattle in a pen vs. no treatment. On days 0 and 26, respectively, pre- and post-trial fecal samples were collected and resistance genes were characterized using shotgun metagenomic sequencing.

Funding

National Institute of Food and Agriculture, 2008-35201-04682

National Institute of Food and Agriculture, 2008-35201-30235

National Institute of Food and Agriculture, 2010-51110-21083

National Institute of Food and Agriculture, 2015-68003-23048

History

Data contact name

BioProject Curation Staff

Publisher

National Center for Biotechnology Information

Temporal Extent Start Date

2017-11-21

Theme

  • Non-geospatial

ISO Topic Category

  • biota

National Agricultural Library Thesaurus terms

sequence analysis

Pending citation

  • No

Public Access Level

  • Public

Accession Number

PRJNA419351

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