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Effect of selenium deficiency and high selenium on biomarkers of selenium status in turkeys

dataset
posted on 2024-01-26, 23:52 authored by University of Wisconsin-Madison
This project generates turkeys with selenium (Se) status that ranges from Se-deficient to high-Se by feeding turkey poults a very low Se basal diet supplemented with graded levels of Se, and then analyzes tissues for selenoenzyme activity, for transcript (mRNA) expression for selenotranscripts and for general transcript expression, and for selenometabolites. These studies show that the dietary selenium requirement of the young turkey poult should be raised to 0.4 ug Se/g as inorganic selenium, and that the turkey is resistant to high dietary Se. These studies further indicate that the FDA limit of dietary selenium supplementation could be safely raised to 0.5 ug Se/g as inorganic selenium, at least for young turkey poults.There are, however, no good biomarkers for excess Se and toxic Se status. Because turkeys appear to be more resistant to Se toxicity, we are focusing on assessing transcripts and selenometabolites in turkeys to identify molecular biomarkers for high Se status. Identified biomarkers have potential as biomarkers to help to determine safe upper limits for dietary Se for turkeys, for other production animals, and for humans.

Funding

U.S. Department of Agriculture, 2013-01043

U.S. Department of Agriculture, Hatch project 1004389

Wisconsin Alumni Foundation (http://www.uwalumni.com), No. 12046295

History

Data contact name

BioProject Curation Staff

Publisher

National Center for Biotechnology Information

Temporal Extent Start Date

2020-03-23

Theme

  • Non-geospatial

ISO Topic Category

  • biota

National Agricultural Library Thesaurus terms

sequence analysis

Pending citation

  • No

Public Access Level

  • Public

Accession Number

PRJNA614544

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