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Determining the Gut Microbiota-dependent Impacts of Anthocyanin-rich Aronia Berries on Obese Individuals of Distinct Inflammatory Phenotypes

posted on 2024-06-11, 06:17 authored by Montana State University
Overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia melanocarpa berries. Inflammation is an underlying mechanism driving the development of several diseases. Microorganisms (microbiome), host tissues, and immune cells residing in the gastrointestinal tract (GIT) are a key source of pro-inflammatory signals that may cause the host organism to become inflamed. Anthocyanins are bioactive compounds with established anti-inflammatory and microbiome altering properties. We hypothesize that the GIT microbiome is a key determinant of host inflammation that can be manipulated by anthocyanin-rich berries to lower inflammation. We assembled a cohort of low inflammation and high inflammation individuals and characterize their GIT microbiome and performed anthropometric measurements, basal measures of metabolism and metabolic health, and examined lipid, metabolomic, and inflammation responses to a high-fat meal challenge. Following this clinical trial, germ-free mice will be humanized with fecal microbial transplants from humans with distinct inflammation phenotypes to determine the impact of Aronia supplementation on the gut microbiome, metabolism, and inflammation.


National Institute of Food and Agriculture, 2017-67018-26367


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BioProject Curation Staff


National Center for Biotechnology Information

Temporal Extent Start Date



  • Non-geospatial

ISO Topic Category

  • biota

National Agricultural Library Thesaurus terms

sequence analysis

Pending citation

  • No

Public Access Level

  • Public

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It is recommended to cite the accession numbers that are assigned to data submissions, e.g. the GenBank, WGS or SRA accession numbers. If individual BioProjects need to be referenced, state that "The data have been deposited with links to BioProject accession number PRJNA596000 in the NCBI BioProject database ("

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