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Data from: Transcriptomic and bioinformatics analysis of the early time-course of the response to prostaglandin F2 alpha in the bovine corpus luteum

posted on 2024-02-09, 18:08 authored by Heather Talbott, Xiaoying Hou, Fang Qiu, Pan Zhang, Chittibabu Guda, Fang Yu, Robert A. Cushman, Jennifer R. Wood, Cheng Wang, Andrea S. Cupp, John S. Davis

RNA expression analysis was performed on the corpus luteum tissue at five time points after prostaglandin F2 alpha treatment of midcycle cows using an Affymetrix Bovine Gene v1 Array. The normalized linear microarray data was uploaded to the NCBI GEO repository (GSE94069). Subsequent statistical analysis determined differentially expressed transcripts ± 1.5-fold change from saline control with P ≤ 0.05. Gene ontology of differentially expressed transcripts was annotated by DAVID and Panther. Physiological characteristics of the study animals are presented in a figure. Bioinformatic analysis by Ingenuity Pathway Analysis was curated, compiled, and presented in tables. A dataset comparison with similar microarray analyses was performed and bioinformatics analysis by Ingenuity Pathway Analysis, DAVID, Panther, and String of differentially expressed genes from each dataset as well as the differentially expressed genes common to all three datasets were curated, compiled, and presented in tables. Finally, a table comparing four bioinformatics tools' predictions of functions associated with genes common to all three datasets is presented. These data have been further analyzed and interpreted in the companion article "Early transcriptome responses of the bovine mid-cycle corpus luteum to prostaglandin F2 alpha includes cytokine signaling".

Resources in this dataset:


USDA-NIFA: 2014–67011-22280

USDA-NIFA: 2011–67015-20076

USDA-NIFA: 2013–67015-20965

USDA: Hatch grant NEB26-202/W2112

USDA: Hatch grant eNEB ANHL 26–213

USDA: Hatch grant NEB 26–206

USDA-ARS: Project Plan 3040–31000-093-00D


Data contact name

Davis, John S.

Data contact email


Data in Brief

Intended use

Study of bovine mid-cycle corpus luteum response to prostaglandin F2 alpha with respect to cytokine activation as a target for improving fertility.


  • Not specified

ISO Topic Category

  • biota
  • farming

National Agricultural Library Thesaurus terms

RNA; corpus luteum; prostaglandins; cows; genes; microarray technology; statistical analysis; gene ontology; animals; bioinformatics; data collection; prediction; transcriptome; cytokines; ruminants; estrous cycle; luteolysis; gene expression; messenger RNA; cyclic AMP; mitogen-activated protein kinase; transcription factor NF-kappa B; interleukins; cattle

OMB Bureau Code

  • 005:18 - Agricultural Research Service

OMB Program Code

  • 005:040 - National Research

Primary article PubAg Handle

Pending citation

  • No

Public Access Level

  • Public

Preferred dataset citation

Talbott, Heather; Hou, Xiaoying; Qiu, Fang; Zhang, Pan; Guda, Chittibabu; Yu, Fang; Cushman, Robert A.; Wood, Jennifer R.; Wang, Cheng; Cupp, Andrea S.; Davis, John S. (2017). Data from: Transcriptomic and bioinformatics analysis of the early time-course of the response to prostaglandin F2 alpha in the bovine corpus luteum. Data in Brief.