Ag Data Commons
Browse
TEXT
Cattle MHC II Non Binder.txt (4.93 GB)
TEXT
Cattle MHC II Weak Binder.txt (609.95 MB)
TEXT
Cattle MHC II Strong Binder.txt (164.61 MB)
TEXT
Sheep and Goat MHC II Non Binders.txt (867.35 MB)
TEXT
Sheep and Goat MHC II SB and WB.txt (128.06 MB)
TEXT
Goat MHCI Non Binder.txt (1.13 GB)
TEXT
Sheep MHCI Non Binder.txt (3.54 GB)
TEXT
Sheep and Goat MHC 1 SB AND WB.txt (109.84 MB)
1/0
8 files

Data from: Expansion of Proteome-wide Coxiella burnetii Comparative T-cell Epitope Prediction to Include Small Ruminant Hosts

dataset
posted on 2023-12-04, 21:48 authored by David SchneiderDavid Schneider, Paige C. Grossman, Robert Kirkpatrick, Stephen N. White, Lindsay M.W. Piel

T-cell epitopes represent sampled environmental- and self-peptides loaded into major histocompatibility complex (MHC) proteins. Bioinformatic tools have been produced to predict these interactions for many species, providing peptides of interest in vaccine development studies.

Prior work by the researchers (DOI: 10.1186/s12859-021-04181-w) assessed the ability of Coxiella burnetii proteins to interact with MHC alleles in human, mouse, and cattle species, the data from which is available on the Open Science Framework repository with accession number RN6QA (DOI: 10.17605/OSF.IO/RN6QA).

Presently, bioinformatic programs NetBoLAIIpan 1.0 and NetMHCpan 4.1 were employed to predict T-cell epitopes within the C. burnetii proteome for the small ruminant species and to expand cattle predictions. The new datasets available herein provide the species, amino acid sequence, position within the protein, GenBank ID, allele name, and the predicted binding strength for each tested peptide.

Funding

Agricultural Research Service, 2090-32000-046-000D

History

Data contact name

Schneider, David A.

Data contact email

david.schneider1@usda.gov

Publisher

Ag Data Commons

Temporal Extent Start Date

2023-02-01

Theme

  • Non-geospatial

ISO Topic Category

  • health

National Agricultural Library Thesaurus terms

Coxiella burnetii; T-lymphocytes; epitopes; prediction; small ruminants; hosts; major histocompatibility complex; proteins; bioinformatics; peptides; vaccine development; alleles; humans; mice; cattle; proteome; data collection; amino acid sequences; bacteriology; subunit vaccines

OMB Bureau Code

  • 005:18 - Agricultural Research Service

OMB Program Code

  • 005:040 - National Research

ARS National Program Number

  • 103

ARIS Log Number

410164

Pending citation

  • Yes

Public Access Level

  • Public

Usage metrics

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC