Ag Data Commons
Vincent_H3N2 HuVac strains.rtf (35.06 kB)

Data from: Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans

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posted on 2024-02-15, 23:00 authored by Carine K. Souza, Tavis K. Anderson, Jennifer Chang, Divya Venkatesh, Nicola S. Lewis, Andrew Pekosz, Kathryn Shaw-Saliba, Richard E. Rothman, Kuan-Fu Chen, Amy L. Vincent

An investigation of antigenic relationships between North American swine H3N2 influenza A viruses (IAV) and human seasonal vaccine strains was conducted to assess the zoonotic risk to humans. Human seasonal H3N2 vaccine strains isolated from 1973 to 2014 (n=20) were obtained from the World Health Organization Global Influenza Surveillance and Response Network through St. Jude Children’s Research Hospital to use for serological assays, such as hemagglutination inhibition (HI) assays. Human seasonal vaccine strains were cultured on MDCK cells or eggs and the HA gene was verified by sequencing on a Sanger method at National Animal Disease Center (NADC). A consensus HA sequence was generated using Geneious Software.

Resources in this dataset:

  • Resource Title: Consensus sequences of hemagglutinin (HA) gene segments.

    File Name: Vincent_H3N2 HuVac strains.rtf

    Resource Description: The data set includes sequences of hemagglutinin (HA) gene of human seasonal influenza A vaccine strains used in hemagglutination inhibition (HI) assays as references to assess the zoonotic risk of North American swine H3N2 strains to humans. The text file lists the consensus sequence of HA gene segment from each human H3N2 influenza A vaccine strain.


USDA-ARS: 0500-00093-001-00-D

National Institute of Allergy and Infectious Diseases: HHSN272201400008C

National Institute of Allergy and Infectious Diseases: HHSN272201400007C

Oak Ridge Institute for Science and Education: DE-AC05-06OR23100


Data contact name

Vincent, Amy L.

Data contact email


Ag Data Commons

Intended use

This data may be used to confirm human H3N2 vaccine strains sequences to study antigenic drift from swine H3N2 influenza A virus.

Temporal Extent Start Date


Temporal Extent End Date



  • Not specified

Geographic Coverage


Geographic location - description

North America

ISO Topic Category

  • biota
  • health

National Agricultural Library Thesaurus terms

swine; humans; Influenza A virus; risk; vaccines; World Health Organization; influenza; monitoring; children; hospitals; immunologic techniques; hemagglutination; eggs; genes; animal diseases; computer software; zoonoses; antigenic variation

OMB Bureau Code

  • 005:18 - Agricultural Research Service

OMB Program Code

  • 005:040 - National Research

ARS National Program Number

  • 103

Pending citation

  • No

Public Access Level

  • Public

Preferred dataset citation

Souza, Carine K.; Anderson, Tavis K.; Chang, Jennifer; Venkatesh, Divya; Lewis, Nicola S.; Pekosz, Andrew; Shaw-Saliba, Kathryn; Rothman, Richard E.; Chen, Kuan-Fu; Vincent, Amy L. (2021). Data from: Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans. Ag Data Commons.

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