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Data From: The 1014F knockdown resistance mutation is not a strong correlate of phenotypic resistance to pyrethroids in Florida populations of Culex quinquefasciatus

posted on 2024-03-04, 23:12 authored by ALDEN ESTEPALDEN ESTEP, Neil Sanscrainte, Jason Stuck, Isik Unlu, Agne Prasauskas, Stephanie J. Mundis, Nicholas Cotter, Ana L. Romero-Weaver, T.J. Fedirko, Natalie Kendziorski, Kyle kosinski, Daviela Ramirez, Eva A. Buckner

Culex quinquefasciatus is an important target for vector control because of its ability to transmit pathogens that cause disease. Most populations are resistant to pyrethroids and often to organophosphates, the two most common classes of active ingredients used by public health agencies. A knockdown resistance (kdr) mutation, resulting in a change from a leucine to phenylalanine in the voltage gated sodium channel, is one mechanism contributing to the pyrethroid resistant phenotype. Enzymatic resistance has also been shown to play a very important role. Recent studies have shown strong resistance in populations even when kdr is relatively low which indicates factors other than kdr may be larger contributors to resistance. In this study, we examined on a statewide scale (over 70 populations), the strength of the correlation between resistance in the CDC bottle bioassay and the kdr genotypes and allele frequencies. Spearman correlation analysis showed only moderate (-0.51) and weak (-0.29) correlation between the kdr genotype and permethrin and deltamethrin respectively. The frequency of the kdr allele was an even weaker correlate. These results indicate, in contrast to Aedes aegypti, assessing kdr in populations of Culex quinquefasciatus is not a good surrogate for phenotypic resistance testing.


US Centers for Disease Control and Prevention: NU50CK000420-04-04


Data contact name

Estep, Alden S.

Data contact email


Ag Data Commons

Temporal Extent Start Date


Temporal Extent End Date



  • unknown


  • Non-geospatial

ISO Topic Category

  • biota
  • health

National Agricultural Library Thesaurus terms

pesticide resistance; mutation; phenotype; pyrethrins; Florida; Culex quinquefasciatus; vector control; disease transmission; pathogens; organophosphorus compounds; active ingredients; public health; leucine; phenylalanine; electric potential difference; sodium channels; bioassays; genotype; gene frequency; permethrin; deltamethrin; alleles; Aedes aegypti

OMB Bureau Code

  • 005:18 - Agricultural Research Service

OMB Program Code

  • 005:040 - National Research

ARS National Program Number

  • 104

Pending citation

  • No

Public Access Level

  • Public