Ag Data Commons
Browse

File(s) stored somewhere else

Please note: Linked content is NOT stored on Ag Data Commons and we can't guarantee its availability, quality, security or accept any liability.

DNA Methylation data from frozen placental tissue

dataset
posted on 2024-01-26, 23:25 authored by Nutritional Immunology and Epigenetics, ARS, USDA
Maternal obesity alters placental tissue function and morphology with a corresponding increase in local inflammation. We and others showed that placenta size, inflammation and fetal growth are regulated by maternal diet and obesity status. Maternal obesity alters placental DNA methylation which in turn could likely impact gene transcription of of proteins critical for normal fetal development. RNA-binding motif single-stranded interacting protein 1 (RBMS1) is expressed by the placenta and likely modulates DNA replication and transcription regulation. Serum RBMS1 protein concentration is increased with maternal obesity and RBMS1 gene expression in liver tissue is induced by a high-fat diet and inflammation. However, it is not yet known whether placental RBMS1 mRNA expression and DNA methylation are altered by maternal obesity. Overall design: Methylation profiles of frozen placental tissue samples from overweight/obese (BMI>25) and non-overweight (BMI

History

Data contact name

BioProject Curation Staff

Publisher

National Center for Biotechnology Information

Temporal Extent Start Date

2018-09-17

Theme

  • Non-geospatial

ISO Topic Category

  • biota

National Agricultural Library Thesaurus terms

epigenetics; genome; genomics

Pending citation

  • No

Public Access Level

  • Public

Accession Number

PRJNA491492

Usage metrics

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC